How to Recognise a Cerebrospinal Fluid (CSF) Leak and When to Seek Medical Help

Have you ever had a headache that worsens when you stand or sit? Picture this: your headache worsens when you’re upright yet eases when you lie down. Sometimes, it even gets progressively worse throughout the day. While there could be various explanations, one possibility is a cerebrospinal fluid leak.

What is Cerebrospinal Fluid?

Cerebrospinal fluid is a transparent liquid that envelops the brain and spinal cord.


Functions of Cerebrospinal Fluid


The cerebrospinal fluid functions as a protective cushion for the delicate neural tissue that it covers. Additionally, it plays a role in supplying nutrients to the brain and facilitating the removal of metabolic waste products from brain tissue.

 

Cerebrospinal fluid is found within the brain’s ventricles, the spinal cord’s central canal, and the subarachnoid space surrounding the brain and spinal cord. It is produced through specialised choroid plexus cells, which actively secrete it into the brain’s ventricles.

The circulation of cerebrospinal fluid plays a crucial role in maintaining brain health. Disruptions in cerebrospinal fluid circulation, such as a cerebrospinal fluid fistula, can lead to complications. Proper cerebrospinal fluid reabsorption, facilitated primarily by structures such as arachnoid villi (small finger-like structures near the brain and spinal cord), is necessary to maintain equilibrium, preventing issues such as fluid buildup, which can exert pressure on the skull. Conversely, conditions like reduced cerebrospinal fluid volume, such as in the case of a leak, can also lead to complications and should be promptly addressed by a healthcare professional.

What is a Cerebrospinal Fluid Leak?

A cerebrospinal fluid leak happens when there is a tear or hole in the membranes surrounding the brain or spinal cord, allowing the clear fluid that surrounds and cushions those organs to escape. This leakage can lead to a decrease in pressure around the brain and spinal cord, a condition known as intracranial hypotension, and other various potential symptoms.

 

Symptoms of a Cerebrospinal Fluid Leak

 

There are two distinct types of cerebrospinal fluid leaks: spinal cerebrospinal fluid leaks and cranial cerebrospinal fluid leaks. 

 

Spinal cerebrospinal leaks can occur anywhere along the spinal column, while cranial leaks take place within the skull. Rarely, cranial leaks may result in clear fluid drainage from the nose or ear. Depending on the severity and site of the tear, cerebrospinal fluid leak symptoms may vary, with some posing a risk of life-threatening complications. 

 

Symptoms from a spinal cerebrospinal fluid leak include:

 

  • A headache that causes pain in the back of the head and improves when lying down
  • Neck or shoulder pain
  • Nausea or vomiting
  • Changes in hearing or ringing in the ears
  • Sensitivity to light and/or sound

 

Symptoms from a cranial cerebrospinal fluid leak include:

 

  • Clear, watery drainage from one side of the nose or ear (Unlike a runny nose, drainage is usually clear and constantly dripping. That said, it may be difficult to distinguish from normal nasal discharge without testing)
  • Loss of smell and/or hearing
  • A salty or metallic taste in the mouth
  • Meningitis (swelling of the protective membranes covering the brain and spinal cord due to an infection)

 

Generally, cerebrospinal fluid leaks can be treated with a thorough medical evaluation. However, if left untreated, they may lead to severe complications, including life-threatening meningitis.

What Causes Cerebrospinal Fluid Leak?

There are several possibilities as to what forms cerebrospinal fluid leaks, such as: 

 

  • Head, brain or spinal surgeries
  • Head injury
  • Spinal tap
  • Epidural

 

Occasionally, a spontaneous cerebrospinal leak occurs without an identifiable cause.

 

How is Cerebrospinal Fluid Leak Diagnosed and Treated?

The diagnosis of a cerebrospinal fluid leak usually begins with a comprehensive physical examination and medical history assessment. Due to the challenge of detecting cerebrospinal fluid leaks, which can lead to misdiagnosis or delayed diagnosis, a thorough examination by a healthcare professional is crucial. 

 

Typically, various tests are employed to evaluate the patient’s condition, including CT scans, MRI scans, myelography (imaging test to look for abnormalities), or radioisotope studies (which entail the injection of chemicals to track cerebrospinal fluid flow and identify a leak).

After a proper diagnosis, doctors can prescribe appropriate cerebrospinal fluid treatments based on the individual needs of the patient. Doctors may recommend complete bed rest for patients with less severe cases for recovery. 

 

Alternatively, if patients do not respond to conservative treatments, doctors may recommend specific procedures. These options might involve a blood patch or surgery, with minimally invasive surgical procedures also being considered when applicable.

Consult Dr Sein Lwin at Advanced Brain and Spine Surgical Centre for Cerebrospinal Fluid Leaks

Recognising that your symptoms may be a sign of a more serious condition is vital, and seeking timely consultation with a specialist is advisable. If you experience intense headaches that worsen with movement or are uncertain about your symptoms, schedule an appointment with a Neuro and Spine Surgeon for a thorough evaluation and diagnosis.

References

  1. Severson, M., Schaurich, C. G., & Strecker-McGraw, M. K. (2023, March 6). Cerebrospinal Fluid Leak. In StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK538157/
  2. Telano, L. N., & Baker, S. (2023, July 4). Physiology, Cerebral Spinal Fluid. In StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK519007/ 
  3. Mayo Foundation for Medical Education and Research. (2023, November 21). CSF leak (cerebrospinal fluid leak). Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/csf-leak/symptoms-causes/syc-20522246